Chalcones are chemical compounds that show hopeful obliging efficacy in controlling numerous diseases. The main objective of the study is to evaluate the in vitro human red blood cell membrane stabilization assay of some novel chalcone derivatives. Four different chalcone derivatives were selected for synthesis by Claisen-Schmidt method. The in vitro human red blood cell membrane stabilization assay was performed for the synthesized compounds. The percentage of membrane stabilization activity was calculated for the synthesized compounds. The IC50 values of the compounds, PC-1, PC-2, PC-3 and PC-4 was found to be 113.94±0.42 µg/mL, 87.38±0.67 µg/mL, 146.67±0.35 µg/mL and 67.97±0.27 µg/mL respectively. The order of potency (IC50) of the chalcone and chalcone oxide in HRBC membrane stabilization assay was PC-4 > PC-2 > PC-1 >PC-3. The IC50 of the standard (Diclofenac) was found to be 37.03±0.16 µg/mL. Further in vivo studies are to be carried out for these compounds to confirm their activity thereby develops a potential drug candidate for inflammation.
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